Ib yam khoom uas tiv thaiv cov tshuaj lom uas pom muaj nyob hauv hiav txwv pwm

Ib yam khoom uas tiv thaiv cov tshuaj lom uas pom muaj nyob hauv hiav txwv pwm
Ib yam khoom uas tiv thaiv cov tshuaj lom uas pom muaj nyob hauv hiav txwv pwm
Anonim

Kev siv tshuaj lom neeg lom los ntawm cov pwm marine Penicillium dimorphosporum tiv thaiv cov cell los ntawm cov tshuaj tua kab tshuaj tua kab uas muaj tshuaj lom ntau, tiv thaiv uas tsis muaj tshuaj tua kab mob, thiab tej zaum tuaj yeem txhim kho qhov kev txiav txim ntawm qee yam tshuaj. Cov kab mob sib kis tau cais los ntawm cov mos mos mos sau hauv South China Sea thaum lub ntoj ke mus kawm ntawm Akademik Oparin tshawb fawb txog ntsha.

Antidote-tso cov pwm yuav pab tua cov tshuaj tua kab ntau heev

Paraquat yog tshuaj tua kab tshuaj tua kab tshuaj lom rau tib neeg thiab tib neeg. Txog ib puas lub tebchaws, suav nrog Tebchaws Meskas, siv nws rau kev cog qoob loo thiab tswj cov nroj. Hauv ntau lub tebchaws, suav nrog Russia, kev siv tshuaj lom lom yog txwv tsis pub siv. Qhov teeb meem ntawm tib neeg lom nrog paraquat tau paub dav hauv Is Nrias teb. Cov neeg ua liaj ua teb uas ua haujlwm tom teb muaj kev pheej hmoo tau txais cov tshuaj txaus ntshai thiab ua rau tuag taus.

FEFU cov kws tshaj lij, ua ke nrog Lavxias thiab cov npoj yaig txawv teb chaws, tau tsim cov khoom sib xyaw los ntawm cov pwm marine Penicillium dimorphosporum tuaj yeem tiv thaiv kev cuam tshuam ntawm paraquat. Qhov kev sim tau ua tiav ntawm kab kab mob neuroblastoma. Los ntawm keeb kwm, cov no yog cov qog nqaij hlav hlwb, uas tau kawm txog kev tiv thaiv neuroprotective (neuroprotective) ntawm cov tshuaj muaj peev xwm.

"Thaum qhov ntsuas qis heev, kwv yees li ib micromole ib litre, cov sib txuas pom tau nce kev muaj peev xwm ntawm cov cell kho nrog paraquat los ntawm yuav luag 40 feem pua piv rau cov cell kho nrog paraquat ib leeg. Hauv chav kawm tshawb fawb ntxiv, peb xav kom piav qhia ntxaws ntxiv tias cov khoom ib txwm muaj tshwm sim no tiv thaiv lub cell li cas. Tej zaum lawv ua cov tshuaj tiv thaiv kab mob, thiab, tej zaum, lawv tseem tuaj yeem tiv thaiv cov cell los ntawm lwm yam tshuaj lom, "hais tias Olesya Zhuravleva, PhD hauv Chemistry, lub taub hau ntawm lub chaw sim tshuaj lom neeg muaj tshuaj lom nyob hauv Tsev Kawm Ntawv Kev Tshawb Fawb Txog Kev Tshawb Fawb ntawm Tsoom Fwv Tebchaws Sab Hnub Tuaj.

Raws li tus kws tshawb fawb, ntau lub ntuj sib txuas muaj qhov tsis zoo uas muaj tsawg ntawm lawv hauv kev tsim cov kab mob rau cov ncauj lus ntxaws.

Hauv qhov kev nkag siab no, hiav txwv nceb Penicillium dimorphosporum tsis muaj qhov tshwj xeeb: nws tsis tsim cov khoom sib xyaw kom ncaj qha ncaj qha. Txawm li cas los xij, ua tsaug rau qhov muaj txiaj ntsig zoo ntawm cov metabolism hauv ntawm cov fungus, pom los ntawm cov kws tshawb fawb, qhov kev txwv tuaj yeem hla dhau. Lub ntsiab lus yog nyob hauv ntau yam isomeric sib txuas uas cov pwm tsim tawm. Lawv muaj tib lub hauv paus ntsiab lus, tab sis cov qauv sib txawv. Nws zoo li ib yam iav nkhaus nkhaus, uas tib txheej txheej ntawm cov atoms tau cuam tshuam ntau zaus thiab ntau txoj hauv kev, muab cov sib xyaw ua haujlwm sib txawv thiab ua rau cov kws tshawb fawb muaj sijhawm los hloov kho lawv. Feem ntau, kev sib sau ua ke ntawm isomers coob tus tsis yog ib txwm muaj rau cov kab mob muaj sia.

"Hauv qhov no, peb npaj yuav kawm kom ntxaws tsis yog cov tshuaj sib xyaw nws tus kheej, tab sis nws cov isomer, uas cov nceb sib xyaw ua ntau ntau, thiab peb tuaj yeem hloov kho nws mus rau lub xeev ntawm cov tshuaj muaj zog. Qhov no yog kev txav mus los zoo heev, vim tias cov khoom uas tsis muaj peev xwm yog qhov nyuaj dua rau kev cais tawm ntawm cov khoom siv ntuj tsim dua li nws yog los hloov qhov uas twb muaj lawm ntau. Piv txwv li, cov nceb ua 200 mg ntawm cov tshuaj tsis muaj zog uas peb tuaj yeem hloov kho kom tsawg li rau rau milligrams ntawm cov khoom ntuj tsim. Ntau cov tshuaj sib xyaw tau txais hauv ib txoj hauv kev zoo ib yam, uas tso cai zam kev nyuaj thiab kim ua kom tiav cov tshuaj sib xyaw, "Olesya Zhuravleva hais. Cov kws tshawb fawb ntawm Far Eastern Federal University (FEFU) thiab Pacific Institute of Bioorganic Chemistry muaj npe tom qab V. I. GB Elyakova hais hauv phau ntawv xov xwm Marine Drugs.

Hauv theem tom ntej, cov kws tshawb fawb npaj yuav kawm kom ntxaws txog cov txheej txheem tiv thaiv kab mob neuroprotective ntawm cov tshuaj sib xyaw ua ke, nrog rau lawv cov peev xwm ua ke nrog lwm cov tshuaj. Raws li qhov kev xav uas tau tshwm sim, cov tshuaj nquag ua haujlwm ntawm cov hmoov av hauv hiav txwv tuaj yeem txhim kho cov txiaj ntsig ntawm qee cov tshuaj paub.

Txoj haujlwm no tau txhawb los ntawm Lavxias Kev Tshawb Fawb Foundation (phiaj xwm 19-74-10014). Txoj kev tshawb fawb koom nrog pab pawg ntawm Far Eastern Federal University, Pacific Institute of Bioorganic Chemistry uas muaj npe tom qab V. I. G. B. Elyakov (TIBOCH FEB RAS), Institute of Chemistry FEB RAS, ntxiv rau cov kws tshaj lij txawv teb chaws los ntawm University Medical Center Hamburg-Eppendorf (Lub Tebchaws Yelemees), Nyab Laj Academy ntawm Kev Tshawb Fawb thiab thev naus laus zis (Institute of Scientific Research and Applied Technologies of Nha Trang).

Dej hiav txwv yog ib qho tseem ceeb ntawm kev tshawb fawb ua haujlwm, sau tseg hauv FEFU txoj haujlwm txhim kho kom txog thaum 2029. Cov kws tshawb fawb hauv tsev kawm qib siab tsis yog tsuas yog tshawb fawb txog kev siv tshuaj sib xyaw ntawm cov hauv paus chiv keeb hauv hiav txwv, tab sis tseem tsim kho cov kev daws teeb meem rau Arctic cov dej khov (tshawb nrhiav thiab tsuas), cov neeg hlau hauv dej, kev sib txuas lus hauv qab dej khov, thiab lwm yam.

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